Past
You can check out the the worlds first recorded sounds at the well named First Sounds.
Present
PLUGGOTIC Shattersync plugin is a lot of fun.
Future
Asus’s Eee is getting cooler. It looks like the little guy is going to have a touch screen version out this summer. CDM just earlier dicussed the Eee as a music maker device. The touchscreen made me think of using it with mono touch. That could be awesome.